Scuola superiore sant'anna

Titolare di assegno di ricerca

Andrea Cafarelli


I obtained a M.Sc. Degree in Biomedical Engineering at University of Pisa in 2013 (full marks, cum laude). In June 2017 I obtained the Ph.D. in Biorobotics (full marks, cum laude) at the BioRobotics Institute of Scuola Superiore Sant'Anna (SSSA), with a thesis regarding innovative therapeutic applications of ultrasound for targeted therapies.

My scientific activity has been characterized from the beginning by a strongly interdisciplinary and curiosity-driven approach. This allowed me to carry out innovative research efforts at the interface between different disciplines, such as robotics, therapeutic ultrasound, ultrasound imaging, materials science, and biotechnologies.

From 2019 I am also co-founder of River Global Scientific Lab srl, a spin-off company of Scuola Superiore Sant’Anna dedicated to technological advances in the therapeutic ultrasound field (e.g. high intensity ultrasound for cancer treatment).

  1. A. Sorriento, A. Poliziani* , A. Cafarelli* , G. Valenza, and L. Ricotti. A novel quantitative and reference-free ultrasound analysis to discriminate different concentrations of bone mineral content. Scientific Reports, 2020  (* Equally contributing authors) (I.F. = 3.998)
  2. L. Morchi, A. Mariani, A. Diodato, S. Tognarelli, A. Cafarelli and A. Menciassi. Acoustic Coupling Quantification in Ultrasound-guided Focused Ultrasound Surgery: simulation-based evaluation and experimental fesibility study. Ultrasound in Medicine and Biology, 2020. (I.F. = 2.514)
  3. A. Novell, H. A. S Kamimura, A. Cafarelli, M. Gerstenmayer, J. Flament, J. Valette, P. Agou, A. Conti, E. Salingue, R. Aron Badin, P. Hantraye & B. Larrat. A new safety index based on intrapulse monitoring of ultra-harmonic cavitation during ultrasound-induced blood-brain barrier opening procedures. Scientific Reports, 2020. (I.F. = 4.011) 
  4. S. Ciancia, A. Cafarelli, A. Zahoranova, A. Menciassi, & L. Ricotti. Pulsatile Drug Delivery System Triggered by Acoustic Radiation Force. Frontiers in Bioengineering and Biotechnology, 2020. (I.F. = 4.21)  
  5. F. Dedola, F. P. U Severino, N. Meneghetti, T. Lemaire, A. Cafarelli, L. Ricotti, A. Menciassi, A. Cutrone, A. Mazzoni & S. Micera. Ultrasound stimulations induce prolonged depolarization and fast action potentials in leech neurons. IEEE Open Journal of Engineering in Medicine and Biology, 2020.
  6. A. Cafarelli, P. Losi, A.R. Salgarella, M.C. Barsotti, I.B. Di Cioccio, I. Foffa, L. Vannozzi, P. Pingue, G. Soldani, L. Ricotti. Small-caliber vascular grafts based on a piezoelectric nanocomposite elastomer: Mechanical properties and biocompatibility. Journal of the mechanical behavior of biomedical materials, 2019. (I.F. = 3.239)
  7. A. Diodato*, A. Cafarelli*, A. Schiappacasse*, S. Tognarelli, G. Ciuti, A. Menciassi. Motion compensation with skin contact control for high intensity focused ultrasound surgery in moving organs. Physics in Medicine and biology, 2018. (* Equally contributing authors) (I.F. = 2.742)
  8. H. A. S. Kamimura, J. Flament, J. Valette, A. Cafarelli, R. A. Badin, P. Hantraye, B. Larrat. Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance. Journal of Cerebral Blood Flow & Metabolism, 2018. (I.F. = 5.081)
  9. A. Cafarelli, L.Ricotti, A. Verbeni, A: Poliziani, P. Dario, A. Menciassi. "Tuning mechanical and acoustic properties of materials for ultrasound phantoms and smart substrates for cell cultures". Acta Biomaterialia, 2016. (I.F. = 6.319)
  10. S. Tognarelli, G. Ciuti, A. Diodato, A. Cafarelli, A. Menciassi. "Robotic Platform for High-Intensity Focused Ultrasound Surgery under Ultrasound Tracking: the FUTURA Platform", Journal of Medical Robotic Research, 2017.
  11. A. R. Salgarella, A. Cafarelli, L. Ricotti, L. Capineri, P. Dario, A. Menciassi. "Optimal ultrasound exposure conditions for maximizing C2C12 muscle cell proliferation and differentiation". Ultrasound in Medicine and Biology, 2017. (I.F. = 2.494)
  12. A. Cafarelli, P. Miloro, A. Verbeni, M. Carbone, and A. Menciassi. “Speed of sound in rubber-based materials for ultrasonic phantoms”. Journal of Ultrasound, 2016.
  13. L. Ricotti, A. Cafarelli*, V. Iacovacci*, L. Vannozzi*, and A. Menciassi. “Advanced Micro-Nano-Bio Systems for Future Targeted Therapies”. Current nanoscience, 2014. (* Equally contributing authors) (I.F.  = 1.24)

My research activity is mainly focused on the development of ultrasound-based systems for therapeutic purposes. In particular my mainly interests are:

  1. characterization of the ultrasound fields;
  2. system design for HIFU and LIPUS applications;
  3. measurement of acoustic properties of materials and tissues;
  4. investigation of physical effects due to the interaction between ultrasound waves and tissues.